Cowan S E, Black J, Keasling J D, White R M
Berkeley Sensor & Actuator Center, Department of Electrical Engineering and Computer Sciences, University of California 94720, USA.
Anal Chem. 1999 Aug 15;71(16):3622-5. doi: 10.1021/ac9809884.
The flexural-plate-wave (FPW) sensor, a type of ultrasonic sensor, can detect changes in E. coli W3110 concentration in solution as the cells settle onto the sensor under the influence of gravity. A model of the sensor's response to cell settling has been developed and is in good agreement with the experimental data. The FPW technique improves on conventional methods for determining cell concentrations; this technique allows for on-line data collection, is nondestructive, and requires only small sample volumes. The FPW sensor has applications as a device to measure cell concentrations and growth rates in industrial fermentors, biofilms, and wastewater treatment facilities.
弯曲板波（FPW）传感器是一种超声传感器，当细胞在重力作用下沉降到传感器上时，它能够检测溶液中大肠杆菌W3110浓度的变化。已经建立了传感器对细胞沉降响应的模型，该模型与实验数据吻合良好。FPW技术改进了测定细胞浓度的传统方法；该技术允许在线数据收集，是非破坏性的，并且只需要少量的样品体积。FPW传感器可作为一种装置，用于测量工业发酵罐、生物膜和废水处理设施中的细胞浓度和生长速率。
