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传统流行病学能否检测出职业性接触农药所导致的癌症风险?

Can traditional epidemiology detect cancer risks caused by occupational exposure to pesticides?

作者信息

Georgellis A, Kolmodin-Hedman B, Kouretas D

机构信息

Environmental Illness Research Center, Huddinge, Sweden.

出版信息

J Exp Clin Cancer Res. 1999 Jun;18(2):159-66.

Abstract

In order to investigate the possible relationship between cancer and occupational exposure to pesticides, we reviewed the latest literature of the epidemiological studies in this area coming to the conclusion that, while several studies indicate a link between certain pesticides and certain tumors, this information is still insufficient, and further research on the health consequences of exposure to pesticides is needed. Moreover, provided there is a risk, it is often too limited to be detected by available epidemiological techniques. Therefore, in addition to the epidemiological studies, the development of new biology, gene technology and medical biotechnology methods may significantly enhance the specificity of the epidemiological studies. Thus, the fusion of molecular biology and epidemiology into molecular epidemiology may provide more specific methods for monitoring the occupational dependent carcinogenic risk of individuals and groups.

摘要

为了调查癌症与职业性接触杀虫剂之间可能存在的关系,我们查阅了该领域流行病学研究的最新文献,得出的结论是,虽然有几项研究表明某些杀虫剂与某些肿瘤之间存在联系,但这些信息仍然不足,需要对接触杀虫剂的健康后果进行进一步研究。此外,即使存在风险,其程度往往也过于有限,无法通过现有的流行病学技术检测出来。因此,除了流行病学研究之外,新生物学、基因技术和医学生物技术方法的发展可能会显著提高流行病学研究的特异性。因此,将分子生物学和流行病学融合为分子流行病学,可能会为监测个体和群体的职业性致癌风险提供更具体的方法。

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