al-Allaf T A, Khuzaie R F, Rashan L J, Halaseh W F
Department of Chemistry, College of Science, University of Mosul, Iraq.
Boll Chim Farm. 1999 Jun;138(6):267-71.
Several dimethyltin dichloride complexes of the general formula Me2SnCl2.L, where L = 8-hydroxy quinoline (L1), 8-hydroxy quinoline-N-oxide (L2),2,6-diaminopyridine (L3), 3-amino aniline (L4), cyclohexyl amine (L5), (1R, 2R)-1,2-cyclohexane diamine (L6), 3,5-dimethylpyrazole (L7), harmaline (L8) and harmine (L9), have been prepared and characterized physicochemically and spectroscopically. It was found that tin coordinated with the active site of these ligands to give complexes with penta-coordinated tin or, to some extent, hexa-coordinated tin. The cytotoxic activities of these complexes have been studied against Hep-2, HeLa, L20B and RD lines using the MTT-colorimetric assay. These activities were compared with those of the three reference standards, cisplatin, carboplatin and oxaliplatin. Some of these complexes exhibited a range of significant activities against the cell lines used, whereas no cytotoxic activities were exhibited by the rest of these complexes. The significance of these results is given and discussed.
制备了通式为Me2SnCl2.L的几种二氯化二甲基锡配合物，其中L = 8-羟基喹啉（L1）、8-羟基喹啉-N-氧化物（L2）、2,6-二氨基吡啶（L3）、3-氨基苯胺（L4）、环己胺（L5）、（1R, 2R）-1,2-环己二胺（L6）、3,5-二甲基吡唑（L7）、骆驼蓬碱（L8）和骆驼蓬灵（L9），并通过物理化学和光谱手段对其进行了表征。发现锡与这些配体的活性位点配位，形成五配位锡配合物，在一定程度上也形成六配位锡配合物。使用MTT比色法研究了这些配合物对Hep-2、HeLa、L20B和RD细胞系的细胞毒性活性。将这些活性与三种参比标准物顺铂、卡铂和奥沙利铂的活性进行了比较。其中一些配合物对所用细胞系表现出一系列显著活性，而其余这些配合物则未表现出细胞毒性活性。给出并讨论了这些结果的意义。
