Rashan L J, al-Allaf T A, Khuzaie R F
Department of Biology, College of Education, University of Mosul, Iraq.
Boll Chim Farm. 1995 Sep;134(8):464-6.
The cytotoxic activities of diorganotin(IV) complexes of some xanthate derivatives; R2Sn(SSCOR'), where R = Me, Bu(n), Ph and R' = C6H11 - (CyX), CH3NHCHCH2 - (MAEX), (CH3)2NCH2CH2 - (DMAEX), (CH3)2NCH2CH(CH3) - (DMAIX) and (C2H5)2NCH2CH2 - (DEAEX), have been studied against Hep-2, Hela, RD, L20B and BGM cell lines using the MTT-colorimetric assay. The present results indicated that moderate activities were demonstrated by the xanthate complexes of Bu(n)2Sn(IV) against four cell lines, whereas no cytotoxic activities were exhibited by both Me2Sn(IV) and Ph2Sn(IV) complexes of the xanthates. These activities were compared with the cytotoxic activities of two reference standards; the cisplatin and paraplatin complexes. The significance of these results is discussed.
一些黄原酸酯衍生物的二有机锡（IV）配合物，即R2Sn(SSCOR')，其中R = 甲基、正丁基、苯基，R' = 环己基 - （CyX）、甲基氨基丙基 - （MAEX）、二甲基氨基乙基 - （DMAEX）、二甲基氨基异丁基 - （DMAIX）和二乙氨基乙基 - （DEAEX），已经使用MTT比色法针对Hep-2、Hela、RD、L20B和BGM细胞系研究了其细胞毒性活性。目前的结果表明，正丁基二锡（IV）的黄原酸酯配合物对四种细胞系表现出中等活性，而黄原酸酯的二甲基锡（IV）和二苯基锡（IV）配合物均未表现出细胞毒性活性。这些活性与两种参考标准物顺铂和卡铂配合物的细胞毒性活性进行了比较。讨论了这些结果的意义。
