Ryan M, Baumann R J
Department of Neurology, University of Kentucky, Lexington 40536-0284, USA.
Pediatr Neurol. 1999 Aug;21(2):523-8. doi: 10.1016/s0887-8994(99)00021-1.
Bromides are no longer a mainstay of epilepsy therapy because of the significant toxicity associated with their use and the availability of safer agents. However, bromides occasionally find a niche in the treatment of patients with refractory seizures, particularly in pediatrics. When the decision to utilize this therapy is made, the clinician may be frustrated by the lack of concise, current information regarding bromides. This review provides an update on the mechanism of action, efficacy, pharmacokinetics, dose, and adverse effects of bromides.
由于溴化物使用时存在显著毒性且有更安全的药物可供使用，它们已不再是癫痫治疗的主要手段。然而，溴化物偶尔会在难治性癫痫患者的治疗中找到一席之地，尤其是在儿科患者中。当决定采用这种治疗方法时，临床医生可能会因缺乏关于溴化物的简洁、最新信息而感到沮丧。本综述提供了关于溴化物作用机制、疗效、药代动力学、剂量和不良反应的最新信息。
