Colombo D, Compostella F, Ronchetti F, Scala A, Toma L, Mukainaka T, Nagatsu A, Konoshima T, Tokuda H, Nishino H
Dipartimento di Chimica e Biochimica Medica, Universitá di Milano, Milan, Italy.
Cancer Lett. 1999 Aug 23;143(1):1-4. doi: 10.1016/s0304-3835(99)00175-5.
Three series of monoacyl-2-O-beta-D-galactosylglycerols bearing an acyl chain of varying length, from C4 to C10, were studied due to their antitumor promoting effects on the activation of the Epstein-Barr virus early antigen (EBV-EA), such activation being induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). This study indicates that it is more the length of the acyl chain that is important for the activity, six carbon atoms resulting in maximum effect, rather than the position of the ester function and the nature of the sugar (galactose or glucose).
研究了三类单酰基-2-O-β-D-半乳糖甘油，其酰基链长度从C4到C10不等，因为它们对爱泼斯坦-巴尔病毒早期抗原（EBV-EA）激活具有抗肿瘤促进作用，这种激活是由肿瘤促进剂12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的。这项研究表明，对于活性而言，更重要的是酰基链的长度，六个碳原子产生最大效果，而不是酯官能团的位置和糖（半乳糖或葡萄糖）的性质。
