氧杂蒽酮作为爱泼斯坦-巴尔病毒激活的抑制剂

Xanthones as inhibitors of Epstein-Barr virus activation.

作者信息

Ito C, Itoigawa M, Furukawa H, Rao K S, Enjo F, Bu P, Takayasu J, Tokuda H, Nishino H

机构信息

Faculty of Pharmacy, Meijo University, Nagoya, Japan.

出版信息

Cancer Lett. 1998 Oct 23;132(1-2):113-7. doi: 10.1016/s0304-3835(98)00173-6.

DOI:10.1016/s0304-3835(98)00173-6

PMID:10397461

Abstract

To search for possible antitumor promoters, we carried out a primary screening of 20 xanthones isolated from plants of the Guttiferae family, using their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells. Some of these xanthones, namely 1,3,7-trihydroxy-2-(3-methyl-2-butenyl)xanthone (8), dulxanthone-B (10) and latisxanthone-C (15), were observed to significantly inhibit the EBV-EA activation. The investigation indicated that 8, 10 and 15 might be valuable antitumor promoters.

摘要

为了寻找可能的抗肿瘤促进剂，我们对从藤黄科植物中分离出的20种氧杂蒽酮进行了初步筛选，利用它们对12-O-十四烷酰佛波醇-13-乙酸酯（TPA）诱导的Raji细胞中爱泼斯坦-巴尔病毒早期抗原（EBV-EA）激活的可能抑制作用。观察到其中一些氧杂蒽酮，即1,3,7-三羟基-2-(3-甲基-2-丁烯基)氧杂蒽酮（8）、双氢氧杂蒽酮-B（10）和拉替氧杂蒽酮-C（15），能显著抑制EBV-EA的激活。研究表明，8、10和15可能是有价值的抗肿瘤促进剂。