Pach J, Targosz D, Kamenczak A
Kliniki Toksykologii KMPiChS Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Przegl Lek. 1999;56(6):472-4.
Intoxication with many xenobiotics cause serious electrolyte abnormalities which require intravenous supplementation. In chronic and acute but not very severe intoxication an oral supplementation of ions can be sufficient. The aim of the study was to evaluate the usefulness of Aspargin for supplementation of potassium and magnesium in chronic alcoholics suffering from withdrawal syndrome. There were 46 study patients, dependent on ethanol treated at the Detoxification Unit of the Department of Clinical Toxicology in Krak w. A differently intensified symptoms of ethanol withdrawal syndrome were noted according to CIWA-A scale in all the patients. Concentration of potassium and magnesium was monitored through the hospitalisation. Except a basic treatment (fluid supplementation, benzodiazepines) also Aspargin (three times a 2 tablets per day) was administered to each of patient for 7 to 10 days. No respiratory, muscular and gastrointestinal symptoms due to hypopotassemia and hypomagnesemia have been noted while hospitalisation in any patient so it could be suspected, that oral supplementation with Aspargin was sufficient to keep these ions balanced. Administration of Aspargin was beneficial to patient and the treatment outcome.
许多外源性物质中毒会导致严重的电解质异常，需要静脉补充。在慢性和急性但不太严重的中毒情况下，口服补充离子可能就足够了。本研究的目的是评估天冬氨酸在患有戒断综合征的慢性酒精中毒患者中补充钾和镁的有效性。有46名依赖乙醇的研究患者在克拉科夫临床毒理学系戒毒科接受治疗。根据CIWA - A量表，所有患者均出现不同程度的乙醇戒断综合征症状。住院期间监测钾和镁的浓度。除了基础治疗（补充液体、苯二氮䓬类药物）外，还对每位患者给予天冬氨酸（每天3次，每次2片），持续7至10天。住院期间，没有任何患者出现因低钾血症和低镁血症引起的呼吸、肌肉和胃肠道症状，因此可以怀疑，口服天冬氨酸足以维持这些离子的平衡。天冬氨酸的给药对患者有益且改善了治疗结果。
