Schwab C, Schulzer M, Steele J C, McGeer P L
Kinsmen Laboratory of Neurological Research, Movement Disorders Centre, University of B.C., Vancouver, Canada.
Neurobiol Aging. 1999 Jan-Feb;20(1):57-63. doi: 10.1016/s0197-4580(99)00005-6.
In diseases such as the Parkinson dementia complex of Guam (PDC) or Alzheimer's disease, susceptible neurons develop intracellular tangles (iNFTs) and then die, leaving behind extracellular tangles (eNFTs). We performed counts of healthy neurons, iNFTs, and eNFTs in the hippocampus of Guamanian Chamorros who were neurologically normal or who suffered from PDC. The total of surviving and dead neurons in the CA4 region was remarkably constant from case to case, indicating that eNFTs are not phagocytosed. Since cases of recent PDC showed only marginal tangle formation in CA4, we concluded that tangle development in CA4 commenced close to the onset of the disease. Based on this assumption, as well as the further assumption that the average rate of tangle development and the average lifetime of a tangled neuron do not alter as the disease progresses, we derived equations to determine the average lifetime of tangled neurons. The results varied from 0.13 years for the most rapidly progressing case to 7.98 years for the most slowly developing case. The average for 8 cases was 2.51 years.
在诸如关岛帕金森痴呆综合征（PDC）或阿尔茨海默病等疾病中，易患病的神经元会形成细胞内缠结（iNFTs），然后死亡，留下细胞外缠结（eNFTs）。我们对神经功能正常或患有PDC的关岛查莫罗人的海马体中的健康神经元、iNFTs和eNFTs进行了计数。CA4区域存活和死亡神经元的总数在不同病例之间显著恒定，这表明eNFTs不会被吞噬。由于近期PDC病例在CA4区域仅显示出少量缠结形成，我们得出结论，CA4区域的缠结形成始于疾病发作附近。基于这一假设，以及进一步假设缠结发展的平均速率和缠结神经元的平均寿命不会随着疾病进展而改变，我们推导了用于确定缠结神经元平均寿命的方程。结果从进展最快的病例的0.13年到发展最慢的病例的7.98年不等。8个病例的平均值为2.51年。
