Geddes J F, Hughes A J, Lees A J, Daniel S E
Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Maida Vale, London, UK.
Brain. 1993 Feb;116 ( Pt 1):281-302. doi: 10.1093/brain/116.1.281.
In recent years a number of patients suffering from long-standing postencephalitic parkinsonism have donated their brains to the United Kingdom Parkinson's Disease Society Brain Bank, in London. In view of the paucity of detailed neuropathological reports of the disease since the 1940s, we have carried out a clinicopathological study of eight recent cases. A spectrum of pathological change was seen, with highly variable involvement of cortical, subcortical and brainstem structures. There was no correlation between severity of disease and severity of pathology. The anatomical distribution of lesions was compared with that seen in progressive supranuclear palsy and Guamanian Parkinson-dementia complex. No definite histological features were identified that could distinguish any of the three disease entities. While the pathogenesis of postencephalitic parkinsonism, progressive supranuclear palsy and Guamanian Parkinson-dementia complex remains unknown, the presence of similar pathologies in these conditions suggests a common disease mechanism, despite the distinctive clinical features.
近年来，一些患有长期脑炎后帕金森综合征的患者将他们的大脑捐赠给了位于伦敦的英国帕金森病协会脑库。鉴于自20世纪40年代以来关于该疾病的详细神经病理学报告较少，我们对最近的8例病例进行了临床病理学研究。观察到一系列病理变化，皮质、皮质下和脑干结构的受累程度差异很大。疾病严重程度与病理严重程度之间没有相关性。将病变的解剖分布与进行性核上性麻痹和关岛帕金森痴呆综合征中的情况进行了比较。未发现能够区分这三种疾病实体的明确组织学特征。虽然脑炎后帕金森综合征、进行性核上性麻痹和关岛帕金森痴呆综合征的发病机制仍然未知，但这些病症中存在相似的病理情况表明，尽管临床特征不同，但存在共同的疾病机制。
