Burkot T R, Clover J R, Happ C M, DeBess E, Maupin G O
Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522-2087, USA.
Am J Trop Med Hyg. 1999 Mar;60(3):453-7. doi: 10.4269/ajtmh.1999.60.453.
The number of Lyme disease cases in Oregon has increased in recent years despite the fact that the pathogen, Borrelia burgdorferi, has never been isolated in the state. Rodent and tick surveys were undertaken in 1997 to isolate and characterize strains of B. burgdorferi from Oregon and to identify potential reservoirs and vectors of Lyme disease. Borrelia burgdorferi was isolated from Neotoma fuscipes, Peromyscus maniculatus, P. boylii, and Ixodes pacificus. Both N. fuscipes and P. maniculatus were infested with I. pacificus and I. spinipalpis. Although I. pacificus infested P. boylii, I. spinipalpis was not found on this rodent, and only 4% of the P. boylii were infected with B. burgdorferi compared with the 19% and 18% infection rates found in N. fuscipes and P. maniculatus, respectively. Variation in the molecular weights of the outer surface proteins A and B were found in these first confirmed isolates of B. burgdorferi from Oregon, as well as truncated forms of outer surface protein B.
尽管俄勒冈州从未分离出莱姆病的病原体伯氏疏螺旋体，但近年来该州莱姆病病例数却有所增加。1997年开展了啮齿动物和蜱虫调查，以从俄勒冈州分离并鉴定伯氏疏螺旋体菌株，并确定莱姆病的潜在宿主和传播媒介。从棕背林鼠、白足鼠、博氏白足鼠和太平洋硬蜱中分离出了伯氏疏螺旋体。棕背林鼠和白足鼠都感染了太平洋硬蜱和刺背硬蜱。虽然太平洋硬蜱感染了博氏白足鼠，但在这种啮齿动物身上未发现刺背硬蜱，且博氏白足鼠感染伯氏疏螺旋体的比例仅为4%，而棕背林鼠和白足鼠的感染率分别为19%和18%。在这些首次从俄勒冈州确认的伯氏疏螺旋体分离株中，发现了外表面蛋白A和B的分子量变异，以及外表面蛋白B的截短形式。
