Flack J M, Kvasnicka J H, Gardin J M, Gidding S S, Manolio T A, Jacobs D R
Wayne State University School of Medicine, the Detroit Medical Center, John D. Dingell Veteran's Affairs Administration Medical Center, MI 48201, USA.
Am Heart J. 1999 Sep;138(3 Pt 1):486-92. doi: 10.1016/s0002-8703(99)70151-1.
To describe the epidemiology of echocardiographic mitral valve prolapse (MVP) and its anthropometric, physiologic, and psychobehavioral correlates with a cross-sectional analysis at 4 urban clinical centers.
A biethnic, community-based sample of 4136 young (aged 23 to 35 years) adult participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who had echocardiograms during their third examination between 1990 and 1991.
Echocardiographic mitral valve prolapse, Doppler mitral regurgitation, blood pressure, anthropometry, and 4 psychobehavioral scales.
Definite echocardiographic MVP prevalence was 0.6% overall and was similar across the 4 ethnicity/sex groups. Most participants (21 of 26, 80%) with definite echocardiographic MVP were unaware of their condition. Relative to persons with normal echocardiograms, those with echocardiographic MVP were taller (174.6 cm vs 171.0 cm, P <.01), leaner (26.7 mm vs 37.4 mm sum of triceps and subscapular skinfolds, P <.01), had lower body mass index (22.0 kg/m(2) vs 26.2 kg/m(2), P <.01), and more often has Doppler mitral regurgitation (34.8% vs 11. 8%, P <.01). Women with echocardiographic MVP had higher ethnicity-adjusted hostility scores (19.9 vs 16.1, P <.05) than women with no MVP. Among 111 (2.7%) of 4136 participants reporting prior physician diagnosis of MVP, only 5 (0.45%) of 111 had definite echocardiographic MVP.
These data document a low prevalence of definite echocardiographic MVP and suggest a constellation of anthropometric, physiologic, and psychobehavioral characteristics in young adults with echocardiographic MVP. Most definite echocardiographic MVP diagnoses were discordant with self-reported MVP status, and false-positive diagnoses of echocardiographic MVP were made more often in women and whites.
通过对4个城市临床中心的横断面分析，描述超声心动图二尖瓣脱垂（MVP）的流行病学及其人体测量学、生理学和心理行为学相关因素。
从基于社区的4136名年轻（23至35岁）成人参与者中选取的双种族样本，这些参与者来自青年动脉粥样硬化风险发展研究（CARDIA），并在1990年至1991年的第三次检查中接受了超声心动图检查。
超声心动图二尖瓣脱垂、多普勒二尖瓣反流、血压、人体测量学指标以及4种心理行为量表。
超声心动图确诊的MVP总体患病率为0.6%，在4个种族/性别组中相似。大多数确诊超声心动图MVP的参与者（26人中的21人，80%）并不知道自己的病情。与超声心动图正常的人相比，超声心动图有MVP的人更高（174.6厘米对171.0厘米，P<.01）、更瘦（肱三头肌和肩胛下皮褶厚度之和为26.7毫米对37.4毫米，P<.01）、体重指数更低（22.0千克/米²对26.2千克/米²，P<.01），并且更常出现多普勒二尖瓣反流（34.8%对11.8%，P<.01）。有超声心动图MVP的女性种族调整后的敌意得分（19.9对16.1，P<.05）高于无MVP的女性。在4136名报告曾被医生诊断为MVP的参与者中，有111人（2.7%），其中只有5人（0.45%）的超声心动图确诊为MVP。
这些数据表明确诊超声心动图MVP的患病率较低，并提示了超声心动图有MVP的年轻人在人体测量学、生理学和心理行为学方面的一系列特征。大多数确诊的超声心动图MVP诊断与自我报告的MVP状态不一致，并且超声心动图MVP的假阳性诊断在女性和白人中更常见。
