Grider G, El-Mallakh R S, Huff M O, Buss T J, Miller J, Valdes R
Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, KY 40292-0001, USA.
J Affect Disord. 1999 Aug;54(3):261-7. doi: 10.1016/s0165-0327(98)00208-0.
A decrease in sodium pump activity in erythrocytes has been associated with manic episodes of bipolar illness relative to euthymic moods. Since red blood cells are long-lived and lack a nucleus, it is likely that a plasma factor is responsible for the observed decrease in sodium pump activity.
Utilizing a radioimmunoassay, we examined the serum concentrations of the digoxin-like immunoreactive factor (DLIF) in ill and well bipolar patients and compared the values to those of normal controls.
DLIF was significantly decreased in manic individuals as compared to normal controls (143.6+/-S.E.M. 20.94 vs. 296.6+/-12.76 pg digoxin equivalents/ml, respectively, F = 4.77, P<0.05), but not compared to euthymic bipolar subjects 213.8+/-86.92, P = 0.77). There were no significant differences in DLIF concentrations between manic and euthymic bipolar individuals (P = 0.8). Since relapse in bipolar patients appears to display a seasonal pattern, we also measured the plasma concentration of this factor over a 12-months period. Normal controls exhibited a seasonal pattern of change in serum DLIF concentrations with a nadir in the winter months. Plasma concentrations of DLIF in bipolar patients did not show a seasonal pattern and maintained low levels throughout the year.
Due to the nonspecificity of our antibody, we could measure only total DLIF. Furthermore, it is unclear what the role of circulating DLIF, if any, may be on brain function.
DLIF may be involved in the pathophysiology of mania.
相对于心境正常而言，红细胞中钠泵活性降低与双相情感障碍的躁狂发作有关。由于红细胞寿命长且无细胞核，很可能是一种血浆因子导致了所观察到的钠泵活性降低。
我们采用放射免疫分析法检测了双相情感障碍患者发病期和缓解期血清中地高辛样免疫反应因子（DLIF）的浓度，并将其与正常对照组的值进行比较。
与正常对照组相比，躁狂个体的DLIF显著降低（分别为143.6±标准误20.94与296.6±12.76 pg地高辛当量/ml，F = 4.77，P<0.05），但与心境正常的双相情感障碍患者相比无显著差异（213.8±86.92，P = 0.77）。躁狂和心境正常的双相情感障碍个体之间的DLIF浓度无显著差异（P = 0.8）。由于双相情感障碍患者的复发似乎呈现季节性模式，我们还在12个月期间测量了该因子的血浆浓度。正常对照组血清DLIF浓度呈现季节性变化模式，冬季最低。双相情感障碍患者的血浆DLIF浓度未呈现季节性模式，全年维持在低水平。
由于我们抗体的非特异性，我们只能测量总DLIF。此外，尚不清楚循环DLIF（如果有的话）对脑功能可能有什么作用。
DLIF可能参与了躁狂的病理生理过程。
