Orellana Ana Maria, Kinoshita Paula Fernanda, Leite Jacqueline Alves, Kawamoto Elisa Mitiko, Scavone Cristoforo
Department of Pharmacology, Institute of Biomedical Science, University of São Paulo , São Paulo , Brazil.
Front Endocrinol (Lausanne). 2016 Feb 16;7:10. doi: 10.3389/fendo.2016.00010. eCollection 2016.
Cardiotonic steroids (CTS) are a class of specific ligands of the Na(+), K(+)- ATPase (NKA). NKA is a P-type ATPase that is ubiquitously expressed and although well known to be responsible for the maintenance of the cell electrochemical gradient through active transport, NKA can also act as a signal transducer in the presence of CTS. Inflammation, in addition to importantly driving organism defense and survival mechanisms, can also modulate NKA activity and memory formation, as well as being relevant to many chronic illnesses, neurodegenerative diseases, and mood disorders. The aim of the current review is to highlight the recent advances as to the role of CTS and NKA in inflammatory process, with a particular focus in the central nervous system.
强心甾体（CTS）是一类Na(+)、K(+)-ATP酶（NKA）的特异性配体。NKA是一种P型ATP酶，广泛表达，虽然众所周知它通过主动转运维持细胞电化学梯度，但在CTS存在的情况下，NKA也可作为信号转导器。炎症除了在驱动机体防御和生存机制方面具有重要作用外，还可调节NKA活性和记忆形成，并且与许多慢性疾病、神经退行性疾病和情绪障碍相关。本综述的目的是强调CTS和NKA在炎症过程中作用的最新进展，特别关注中枢神经系统。
