Honey K, Cobbold S P, Waldmann H
Sir William Dunn School of Pathology, Oxford, UK.
Immunol Res. 1999;20(1):1-14. doi: 10.1007/BF02786503.
Transplantation tolerance can be induced by a range of agents that block T cell/antigen-presenting cell (APC) interactions known to be important for initiation of the adaptive immune response. Tolerance so induced has been shown to have a regulatory phenotype dependent on CD4+ cells. This was first observed with nonlytic anti-CD4 antibodies, and was recently demonstrated following other therapeutic approaches. Dominant tolerance also plays a role in natural regulation of the immune response, functioning to prevent autoaggressive cells mediating self-destruction. The mechanism by which dominant tolerance is established and maintained remains unclear, and the reported characteristics of regulatory cells in different experimental models vary widely. Here we review the evidence for potential mechanisms involved and propose that there is a common pathway by which dominant tolerance is mediated.
一系列能够阻断T细胞/抗原呈递细胞（APC）相互作用的因子可诱导移植耐受，已知这种相互作用对适应性免疫反应的启动很重要。如此诱导产生的耐受已被证明具有依赖于CD4+细胞的调节表型。这一现象最初是在使用非裂解性抗CD4抗体时观察到的，最近在其他治疗方法后也得到了证实。显性耐受在免疫反应的自然调节中也发挥作用，其功能是防止自身攻击性细胞介导自我破坏。显性耐受建立和维持的机制仍不清楚，并且在不同实验模型中报道的调节性细胞特征差异很大。在这里，我们回顾了涉及潜在机制的证据，并提出存在一条介导显性耐受的共同途径。
