Waldmann H, Cobbold S
Department of Pathology, University of Cambridge, UK.
Curr Opin Immunol. 1993 Oct;5(5):753-8. doi: 10.1016/0952-7915(93)90133-d.
Non-lytic antibodies to CD4 and certain other T cell adhesion receptors can guide the immune system to become tolerant to foreign antigens, and to regain tolerance in autoimmunity. Tolerance is maintained lifelong through the action of regulatory T cells that in turn can influence naive T cells to acquire the same regulatory properties. A fuller understanding of the molecular basis of infectious tolerance could lead to the design of better immunosuppressive protocols.
针对CD4和某些其他T细胞黏附受体的非溶细胞性抗体可引导免疫系统对外源抗原产生耐受性，并在自身免疫中恢复耐受性。通过调节性T细胞的作用，耐受性可终身维持，而调节性T细胞又可影响幼稚T细胞获得相同的调节特性。更全面地了解感染性耐受的分子基础可能会带来更好的免疫抑制方案的设计。
