Vierra E, Cunningham B B
Department of Medicine (Dermatology), University of California at San Diego, Children's Hospital and Health Center, USA.
Semin Cutan Med Surg. 1999 Sep;18(3):210-25. doi: 10.1016/s1085-5629(99)80019-4.
Localized scleroderma refers to a diverse spectrum of disorders that involve fibrosis of the skin. Children are more likely than adults to develop localized forms of scleroderma. This condition may have devastating effects on growth and development such as limb asymmetry, flexion contractures, and psychological disability. The pathogenesis of localized scleroderma is unknown but its possible relation to Borrelial infection is discussed. This article reviews associated laboratory and radiologic abnormalities, and discusses implications for monitoring disease activity. There is no universally effective therapy for this idiopathic condition and therapy is limited. A rationale for treatment based on disease subtype and severity is provided.
局限性硬皮病指的是一系列涉及皮肤纤维化的疾病。儿童比成人更易患上局限性硬皮病。这种病症可能对生长发育产生严重影响，如肢体不对称、屈曲挛缩和心理障碍。局限性硬皮病的发病机制尚不清楚，但讨论了其与疏螺旋体感染的可能关系。本文回顾了相关的实验室及影像学异常表现，并探讨了监测疾病活动的意义。对于这种特发性病症，尚无普遍有效的治疗方法，治疗手段有限。本文还提供了基于疾病亚型和严重程度的治疗依据。
