Pogorzelska-Antkowiak Anna, Antkowiak Ryszard
Katedry i Zakładu Histologii w Zabrzu Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 2006;59(5-6):392-5.
Scleroderma is the autoimmunologic disease with induration and fibrosis of the skin, subcutaneous tissue; sometimes refers to muscles, bones and other internal organs. Pathogenesis of morphea is still unknown. There are two main types of scleroderma: the first type is related only to the skin (localized scleroderma--morphea), while the second is connected with fibrosis and induration of the skin, lungs, heart and other organs (systemic sclerosis). There are various clinical forms of scleroderma circumscripta: linear scleroderma (the most frequent in children), morphea en plaque, generalized morphea, nodular and keloidea like, morphea guttata, scleroderma circumscripta with blisters on the surface-bullous morphea. Morphea profunda is the most severe type of scleroderma localized on the skin. Although the diagnosis of morphea is not so difficult, the treatment is problematic and not very effective. It is very important to initiate the proper treatment as soon as possible. There are three main ways of morphea treatment: medication (receiving local or per os), physical methods (for example phototherapy) and balneotherapy or climatic treatment.
硬皮病是一种自身免疫性疾病，可导致皮肤、皮下组织硬化和纤维化；有时也涉及肌肉、骨骼和其他内脏器官。硬斑病的发病机制尚不清楚。硬皮病主要有两种类型：第一种仅累及皮肤（局限性硬皮病——硬斑病），而第二种与皮肤、肺、心脏和其他器官的纤维化和硬化有关（系统性硬化症）。硬斑病有多种临床类型：线状硬皮病（在儿童中最常见）、斑块状硬斑病、泛发性硬斑病、结节状和瘢痕疙瘩样硬斑病、点滴状硬斑病、表面有水泡的局限性硬皮病——大疱性硬斑病。深部硬斑病是局限于皮肤的最严重类型的硬皮病。虽然硬斑病的诊断并不困难，但治疗存在问题且效果不太理想。尽早开始适当治疗非常重要。硬斑病的治疗主要有三种方法：药物治疗（局部用药或口服）、物理方法（如光疗）和浴疗或气候疗法。
