Nauman E A, Fong K E, Keaveny T M
Department of Mechanical Engineering, University of California, Berkeley, USA.
Ann Biomed Eng. 1999 Jul-Aug;27(4):517-24. doi: 10.1114/1.195.
The structure-function relationships for the permeability of trabecular bone may have relevance for tissue engineering, total joint replacements, and whole bone mechanics. To investigate such relationships, we used a constant flow rate permeameter to determine the intrinsic permeability of trabecular bone specimens, oriented longitudinally or transversely to the principal trabecular orientation, from the human vertebral body (n=20), human proximal femur (n=12), and bovine proximal tibia (n=24). Overall, the intertrabecular permeability ranged from 2.68 x 10(-11) to 2.00 x 10(-8) m2. Significant negative nonlinear relations between intertrabecular permeability and volume fraction were found for each group except the longitudinal bovine proximal tibial specimens (r2=0.34-0.80). The average permeability ratio, a measure of the anisotropy, was 2.05, 6.60, and 23.3 for the human vertebral body, bovine tibia, and human femur, respectively. The permeability depended strongly on flow direction relative to the principal trabecular orientation (p<0.0001) and anatomic site (p <0.0001). In addition to providing a comprehensive description of intertrabecular permeability as a function of anatomic site and flow direction, these data provide substantial insight into the underlying structure-function relationships.
松质骨渗透性的结构 - 功能关系可能与组织工程、全关节置换和整个骨骼力学相关。为了研究此类关系，我们使用恒流速率渗透仪来测定来自人类椎体（n = 20）、人类近端股骨（n = 12）和牛近端胫骨（n = 24）的、沿主要小梁方向纵向或横向定向的松质骨标本的固有渗透率。总体而言，小梁间渗透率范围为2.68×10⁻¹¹至2.00×10⁻⁸ m²。除纵向牛近端胫骨标本外，每组均发现小梁间渗透率与体积分数之间存在显著的负非线性关系（r² = 0.34 - 0.80）。作为各向异性度量的平均渗透率比，人类椎体、牛胫骨和人类股骨分别为2.05、6.60和23.3。渗透率强烈依赖于相对于主要小梁方向的流动方向（p < 0.0001）和解剖部位（p < 0.0001）。这些数据除了全面描述小梁间渗透率作为解剖部位和流动方向的函数外，还为潜在的结构 - 功能关系提供了深入见解。
