Gin I, Chew J, Rau K A, Amos D B, Bridenstine J B
Department of Dermatology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA.
Dermatol Surg. 1999 Jun;25(6):468-73; discussion 473-4. doi: 10.1046/j.1524-4725.1999.09012.x.
High-energy pulsed or computer-scanned continuous-wave carbon dioxide (CO2) laser resurfacing has gained popularity as a wrinkle treatment because of its minimal thermal injury and precise control of tissue vaporization depth. Manual tumescent dermabrasion has also been effective for treating facial wrinkles. This is, to our knowledge, the first study comparing the use of CO2 laser to manual tumescent dermabrasion for the treatment of wrinkles on the upper lip.
To compare prospectively the clinical efficacy of the 950 microsec dwell time CO2 laser to that of manual tumescent dermabrasion in the treatment of upper lip wrinkles.
Twenty female subjects with moderate to severe upper lip wrinkles were randomly treated with the 950 microsec dwell time CO2 laser on one side of the upper lip and manual tumescent dermabrasion on the other.
The average upper lip laser-treated wrinkle score (0 = none to 5 = severe) decreased from 4.3 +/- 0.2 before treatment to 1.8 +/- 0.3 at 6 months after treatment. The average upper lip dermabrasion-treated wrinkle score decreased from 4.4 +/- 0.2 to 1.5 +/- 0.3. The degree to which the wrinkle score improved after laser treatment compared with that after dermabrasion was not statistically significant (P =.216).
Manual tumescent dermabrasion and 950 microsec dwell time CO2 laser resurfacing are equally effective for the treatment of upper lip wrinkles.
高能脉冲或计算机扫描连续波二氧化碳（CO₂）激光换肤术因其热损伤极小且能精确控制组织汽化深度，作为一种皱纹治疗方法已受到广泛欢迎。手动肿胀磨皮术在治疗面部皱纹方面也很有效。据我们所知，这是第一项比较CO₂激光与手动肿胀磨皮术治疗上唇皱纹效果的研究。
前瞻性比较950微秒驻留时间的CO₂激光与手动肿胀磨皮术治疗上唇皱纹的临床疗效。
20名患有中度至重度上唇皱纹的女性受试者，一侧上唇随机接受950微秒驻留时间的CO₂激光治疗，另一侧接受手动肿胀磨皮术治疗。
激光治疗的上唇皱纹平均评分（0 = 无至5 = 严重）从治疗前的4.3±0.2降至治疗后6个月的1.8±0.3。磨皮术治疗的上唇皱纹平均评分从4.4±0.2降至1.5±0.3。激光治疗后皱纹评分改善程度与磨皮术后相比，差异无统计学意义（P = 0.216）。
手动肿胀磨皮术和950微秒驻留时间的CO₂激光换肤术在治疗上唇皱纹方面同样有效。
