Nguyen T N, Barkun A N, Fallone C A
Division of Gastroenterology, McGill University, Montreal, Quebec, Canada.
Helicobacter. 1999 Sep;4(3):185-97. doi: 10.1046/j.1523-5378.1999.99294.x.
Greater than one-half of the world's population harbors Helicobacter pylori. The majority of infected individuals, however, remain asymptomatic, with only 10% to 20% developing diseases, including peptic ulcer disease, gastric cancer, and gastric mucosa-associated lymphoid tissue lymphoma. This article reviews host factors that may predispose an individual to both the acquisition of H. pylori infection and subsequent clinical outcome. Individuals with specific blood group antigens and human leukocyte antigen genotypes may be more susceptible to H. pylori infection. Additional factors, such as the age of acquisition, the host immune response, the site of infection, acid secretion, and interactions with nonhost factors (including bacterial virulence factors and environmental influences) may play a role in determining clinical outcome. Further investigation is required to clarify the mechanisms by which these interactions occur and, more critically, to determine their relative importance. This knowledge will enable the identification of individuals at risk of developing clinical disease with H. pylori infection.
全球超过一半的人口感染幽门螺杆菌。然而，大多数感染者并无症状，只有10%至20%的人会患上包括消化性溃疡病、胃癌和胃黏膜相关淋巴组织淋巴瘤在内的疾病。本文综述了可能使个体易感染幽门螺杆菌并影响后续临床结局的宿主因素。具有特定血型抗原和人类白细胞抗原基因型的个体可能更容易感染幽门螺杆菌。其他因素，如感染年龄、宿主免疫反应、感染部位、胃酸分泌以及与非宿主因素的相互作用（包括细菌毒力因子和环境影响），可能在决定临床结局中发挥作用。需要进一步研究以阐明这些相互作用发生的机制，更关键的是，确定它们的相对重要性。这些知识将有助于识别感染幽门螺杆菌后有临床疾病风险的个体。
