CD137诱导的细胞凋亡不依赖于CD95。
CD137-induced apoptosis is independent of CD95.
作者信息
Michel J, Pauly S, Langstein J, Krammer P H, Schwarz H
机构信息
Department of Pathology, University of Regensburg, Regensburg, Germany.
出版信息
Immunology. 1999 Sep;98(1):42-6. doi: 10.1046/j.1365-2567.1999.00851.x.
Abstract
CD95 (APO-1/Fas) and CD137 (ILA/4-1BB) are members of the tumour necrosis factor receptor family, and both are involved in induction of apoptosis in lymphocytes. Contrary to the case of CD95, apoptosis by CD137 is caused by cross-linking of the respective ligand rather than the receptor. Nothing is known so far about the mechanism of CD137-induced cell death. Here, we show that immobilized CD137 protein induces expression of CD95 in resting primary T and B lymphocytes. However, induction of apoptosis by CD137 is independent of CD95, because: (1) antagonistic anti-CD95 antibody fragments do not block CD137-induced apoptosis; and (2) CD137, but not anti-CD95, can induce apoptosis in resting lymphocytes.
摘要
CD95（APO-1/Fas）和CD137（ILA/4-1BB）是肿瘤坏死因子受体家族的成员，二者均参与淋巴细胞凋亡的诱导过程。与CD95的情况相反，CD137诱导的凋亡是由相应配体而非受体的交联所引起的。迄今为止，关于CD137诱导细胞死亡的机制尚不清楚。在此，我们表明固定化的CD137蛋白可诱导静息原代T淋巴细胞和B淋巴细胞中CD95的表达。然而，CD137诱导的凋亡不依赖于CD95，原因如下：（1）拮抗型抗CD95抗体片段不能阻断CD137诱导的凋亡；（2）CD137而非抗CD95能够诱导静息淋巴细胞凋亡。
相似文献
1
CD137-induced apoptosis is independent of CD95.CD137诱导的细胞凋亡不依赖于CD95。
Immunology. 1999 Sep;98(1):42-6. doi: 10.1046/j.1365-2567.1999.00851.x.
2
CD137 (ILA/4-1BB), expressed by primary human monocytes, induces monocyte activation and apoptosis of B lymphocytes.由原代人单核细胞表达的CD137（ILA/4-1BB）可诱导单核细胞活化及B淋巴细胞凋亡。
Int Immunol. 2000 Jan;12(1):73-82. doi: 10.1093/intimm/12.1.73.
3
Defective expression of the apoptosis-inducing CD95 (Fas/APO-1) molecule on T and B cells in IDDM.胰岛素依赖型糖尿病患者T细胞和B细胞上凋亡诱导分子CD95（Fas/APO-1）表达缺陷。
Diabetologia. 1995 Dec;38(12):1449-54. doi: 10.1007/BF00400606.
4
Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.Fas抗原刺激可诱导人类免疫缺陷病毒感染个体的T淋巴细胞发生明显凋亡。
J Exp Med. 1995 Jun 1;181(6):2029-36. doi: 10.1084/jem.181.6.2029.
5
CD137 activation abrogates granulocyte-macrophage colony-stimulating factor-mediated anti-apoptosis in neutrophils.CD137激活可消除粒细胞-巨噬细胞集落刺激因子介导的中性粒细胞抗凋亡作用。
Eur J Immunol. 2000 Dec;30(12):3441-6. doi: 10.1002/1521-4141(2000012)30:12<3441::AID-IMMU3441>3.0.CO;2-L.
6
Functional CD137 receptors are expressed by eosinophils from patients with IgE-mediated allergic responses but not by eosinophils from patients with non-IgE-mediated eosinophilic disorders.功能性CD137受体在IgE介导的过敏反应患者的嗜酸性粒细胞中表达，但在非IgE介导的嗜酸性粒细胞疾病患者的嗜酸性粒细胞中不表达。
J Allergy Clin Immunol. 2001 Jul;108(1):21-8. doi: 10.1067/mai.2001.116864.
7
8
Rapid induction of CD95 ligand and CD4+ T cell-mediated apoptosis by CD137 (4-1BB) costimulation.通过CD137（4-1BB）共刺激快速诱导CD95配体和CD4 + T细胞介导的细胞凋亡。
Eur J Immunol. 2001 May;31(5):1410-6. doi: 10.1002/1521-4141(200105)31:5<1410::AID-IMMU1410>3.0.CO;2-H.
9
CD137 expression in tumor vessel walls. High correlation with malignant tumors.肿瘤血管壁中的CD137表达。与恶性肿瘤高度相关。
Am J Clin Pathol. 2001 Apr;115(4):543-9. doi: 10.1309/e343-kmyx-w3y2-10ky.
10
Constitutive expression of functional 4-1BB (CD137) ligand on carcinoma cells.
J Immunol. 2000 Sep 1;165(5):2903-10. doi: 10.4049/jimmunol.165.5.2903.
引用本文的文献
1
Is Associated with Favorable Tumor Immune Microenvironment in Patients with Renal Cell Carcinoma Who Are Treated with the Combination Therapy of Nivolumab and Ipilimumab.与接受纳武利尤单抗和伊匹单抗联合治疗的肾细胞癌患者的有利肿瘤免疫微环境相关。
Int J Mol Sci. 2024 Jul 6;25(13):7444. doi: 10.3390/ijms25137444.
2
Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting.横纹肌肉瘤异位表达CD137可提供选择优势，但可实现免疫治疗靶向。
Oncoimmunology. 2021 Feb 4;10(1):1877459. doi: 10.1080/2162402X.2021.1877459.
3
CD137 ligand-mediated reverse signaling inhibits proliferation and induces apoptosis in non-small cell lung cancer.CD137配体介导的反向信号传导抑制非小细胞肺癌的增殖并诱导其凋亡。
Med Oncol. 2015 Mar;32(3):44. doi: 10.1007/s12032-015-0499-9. Epub 2015 Jan 29.
4
4-1BB ligand signaling to T cells limits T cell activation.4-1BB配体向T细胞发出的信号会限制T细胞的激活。
J Immunol. 2015 Jan 1;194(1):134-41. doi: 10.4049/jimmunol.1401383. Epub 2014 Nov 17.
5
Cross-linking of CD137 ligand modulates immune responses of thioglycollate-elicited mouse peritoneal macrophages.交联 CD137 配体调节硫代乙醇酸盐诱导的小鼠腹腔巨噬细胞的免疫反应。
Inflamm Res. 2011 May;60(5):467-73. doi: 10.1007/s00011-010-0289-y. Epub 2010 Dec 24.
本文引用的文献
1
Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway.通过共刺激分子4-1BB配体的基因转移增强肿瘤免疫：与CD28共刺激途径的协同作用。
Eur J Immunol. 1998 Mar;28(3):1116-21. doi: 10.1002/(SICI)1521-4141(199803)28:03<1116::AID-IMMU1116>3.0.CO;2-A.
2
3
A soluble form of CD137 (ILA/4-1BB), a member of the TNF receptor family, is released by activated lymphocytes and is detectable in sera of patients with rheumatoid arthritis.肿瘤坏死因子受体家族成员之一的可溶性CD137（ILA/4-1BB）可由活化的淋巴细胞释放，且在类风湿关节炎患者的血清中可检测到。
Eur J Immunol. 1998 Jan;28(1):290-5. doi: 10.1002/(SICI)1521-4141(199801)28:01<290::AID-IMMU290>3.0.CO;2-S.
4
CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies.
Biochem Biophys Res Commun. 1997 Jun 27;235(3):699-703. doi: 10.1006/bbrc.1997.6870.
5
Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors.针对4-1BB T细胞活化分子的单克隆抗体可根除已形成的肿瘤。
Nat Med. 1997 Jun;3(6):682-5. doi: 10.1038/nm0697-682.
6
Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB.4-1BBL与层粘连蛋白结合至肿瘤坏死因子受体超家族成员小鼠4-1BB的分析及与人类4-1BB的比较。
J Biol Chem. 1997 Mar 7;272(10):6448-56. doi: 10.1074/jbc.272.10.6448.
7
Costimulation of CD28- T lymphocytes by 4-1BB ligand.4-1BB配体对CD28阴性T淋巴细胞的共刺激作用。
J Immunol. 1997 Jan 15;158(2):551-9.
8
cis-9,10-octadecenoamide, an endogenous sleep-inducing CNS compound, inhibits lymphocyte proliferation.
Res Immunol. 1996 Jul-Aug;147(6):389-96. doi: 10.1016/0923-2494(96)82047-5.
9
The nerve growth factor/tumor necrosis factor receptor family.神经生长因子/肿瘤坏死因子受体家族
J Leukoc Biol. 1996 Jul;60(1):1-7. doi: 10.1002/jlb.60.1.1.
10
The origin of programmed cell death.程序性细胞死亡的起源。
Science. 1996 May 31;272(5266):1278-9. doi: 10.1126/science.272.5266.1278.
Zotero 插件