受体信号传导：当二聚化并不足够时。
Receptor signaling: when dimerization is not enough.
作者信息
Jiang G, Hunter T
机构信息
Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
出版信息
Curr Biol. 1999;9(15):R568-71. doi: 10.1016/s0960-9822(99)80357-1.
Abstract
Activation of receptors that signal via tyrosine kinase domains has been thought to involve receptor dimerization and transphosphorylation of juxtaposed catalytic domains. Recent results suggest things might be more complex - specific intersubunit conformational changes within a dimer can also be important.
摘要
人们一直认为，通过酪氨酸激酶结构域发出信号的受体激活涉及受体二聚化以及相邻催化结构域的反式磷酸化。最近的研究结果表明，情况可能更为复杂——二聚体内特定的亚基间构象变化也可能很重要。
Zotero 插件