Transmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: case report.

作者信息

Kamischke A, Gromoll J, Simoni M, Behre H M, Nieschlag E

机构信息

Institute of Reproductive Medicine and Department of Obstetrics and Gynaecology of the University, Domagkstr. 11, D-48129 Münster, Germany.

出版信息

Hum Reprod. 1999 Sep;14(9):2320-2. doi: 10.1093/humrep/14.9.2320.

The transmission of a deleted in azoospermia (DAZ) deletion from a severely oligozoospermic patient to his son following intracytoplasmic sperm injection (ICSI) treatment is reported. The case report highlights the fertilizing capacity of spermatozoa carrying Y chromosome deletions in patients treated with ICSI and stresses the importance of genetic counselling in severe male infertility.