Morgante G, Ditto A, La Marca A, De Leo V
Department of Obstetrics and Gynaecology, University of Siena, 53100 Siena, Italy.
Hum Reprod. 1999 Sep;14(9):2371-4. doi: 10.1093/humrep/14.9.2371.
The most effective therapy for endometriosis is a matter for debate. The aim of the present randomized study was to evaluate the efficacy of low doses of danazol on recurrence of pelvic pain in patients with moderate or severe endometriosis, who had undergone laparoscopic surgery and 6 months of gonadotrophin-releasing hormone analogue (GnRHa) therapy. After surgery, 28 patients with moderate or severe endometriosis underwent therapy for 6 months with GnRHa i. m. every 4 weeks. They were then randomized into two groups: group A (14 subjects) was treated with 100 mg/day danazol for 6 months; group B (14 subjects, control) did not receive any type of therapy. After 12 months of treatment, group A had a significantly (P < 0.01) lower pain score than group B. There was no significant difference between the groups in oestrogen concentrations, bone mineral density or side-effects. The results suggest that low-dose danazol therapy reduces recurrence of pelvic pain in patients with moderate or severe endometriosis, treated surgically, and has few or no metabolic side-effects.
子宫内膜异位症最有效的治疗方法仍存在争议。本随机研究的目的是评估低剂量达那唑对中度或重度子宫内膜异位症患者盆腔疼痛复发的疗效，这些患者均接受了腹腔镜手术及6个月的促性腺激素释放激素类似物（GnRHa）治疗。术后，28例中度或重度子宫内膜异位症患者每4周接受一次GnRHa肌肉注射治疗，为期6个月。然后将他们随机分为两组：A组（14名受试者）接受100mg/天达那唑治疗6个月；B组（14名受试者，对照组）未接受任何治疗。治疗12个月后，A组的疼痛评分显著低于B组（P<0.01）。两组在雌激素浓度、骨密度或副作用方面无显著差异。结果表明，低剂量达那唑治疗可降低接受手术治疗的中度或重度子宫内膜异位症患者盆腔疼痛的复发率，且几乎没有代谢副作用。
