Kaplan S L
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Infect Dis Clin North Am. 1999 Sep;13(3):579-94, vi-vii. doi: 10.1016/s0891-5520(05)70095-7.
The clinical presentations of children and adults with bacterial meningitis have not changed over the past several decades, and a high index of suspicion remains critical for timely identification of infected patients. With the virtual disappearance of H. influenzae type B meningitis (Hib) in areas of the world where Hib conjugate vaccine is administered routinely, the utility of commercially available tests for rapid detection of bacterial polysaccharides has diminished. Detection of gene products of meningeal pathogens in cerebrospinal fluid or blood is still experimental. The prognostic findings of recent studies are not different from those previously described, despite advances in the supportive care of critically ill patients.
在过去几十年中，儿童和成人细菌性脑膜炎的临床表现并无变化，高度的怀疑指数对于及时识别感染患者仍然至关重要。在常规接种B型流感嗜血杆菌（Hib）结合疫苗的地区，Hib脑膜炎几乎消失，市售的快速检测细菌多糖的检测方法的效用已经降低。在脑脊液或血液中检测脑膜病原体的基因产物仍处于实验阶段。尽管危重症患者的支持治疗有所进展，但最近研究的预后结果与先前描述的并无不同。
