Takigawa N, Segawa Y, Nakata M, Saeki H, Mandai K, Kishino D, Shimono M, Ida M, Eguchi K
Department of Internal Medicine, National Shikoku Cancer Center Hospital, Matsuyama, Japan.
Lung Cancer. 1999 Aug;25(2):115-21. doi: 10.1016/s0169-5002(99)00055-0.
The clinicopathologic characteristics of atypical adenomatous hyperplasia (AAH) remain unclear. A total of 137 patients underwent resection for adenocarcinoma of the lung at our institution. Examination of resected lung tissue showed that in addition to adenocarcinoma AAH was present in 26 cases and was not present in 111 cases. All nonsmokers with AAH (n = 13) had earlier-stage disease (stage IA, IB, IIA, and IIB) and no history of respiratory disease. Among patients with stage IA disease, the relapse-free and overall survival curves for those with AAH (n = 14) tended to be better than for those without AAH (n = 40), but the difference was not statistically significant (P = 0.056 and 0.087, respectively). Concurrent presence of AAH may be a favorable prognostic indicator in patients with stage IA adenocarcinoma.
非典型腺瘤样增生（AAH）的临床病理特征仍不明确。在我们机构，共有137例患者接受了肺癌切除术。对切除的肺组织检查显示，除腺癌外，26例存在AAH，111例不存在AAH。所有患有AAH的非吸烟者（n = 13）疾病分期较早（IA期、IB期、IIA期和IIB期），且无呼吸系统疾病史。在IA期疾病患者中，患有AAH的患者（n = 14）的无复发生存曲线和总生存曲线往往比未患AAH的患者（n = 40）更好，但差异无统计学意义（分别为P = 0.056和0.087）。AAH的同时存在可能是IA期腺癌患者的一个有利预后指标。
