Czachowski C L, Samson H H, Denning C E
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1083, USA.
Alcohol Clin Exp Res. 1999 Aug;23(8):1331-5.
The addition of sucrose to ethanol solutions results in a substantial increase in ethanol self-administration by rats that are deprived of neither food nor water. However, if sucrose alters ethanol absorption or metabolism, resulting in blood ethanol concentrations (BECs) not different from those resulting from lower intakes of ethanol/water solutions, then the usefulness of sucrose/ethanol mixtures in increasing ethanol consumption is questionable. The present study was conducted to determine whether the addition of sucrose to ethanol solutions altered BECs in an operant self-administration paradigm.
Tail blood (from male Long-Evans rats) was collected 30 min after the intake of four different solutions, i.e., 5% sucrose/20% ethanol, 5% sucrose/10% ethanol, 2% sucrose/10% ethanol, and 10% ethanol.
Ethanol intakes (mean, 1.57+/-0.21 g/kg) and BECs (mean, 78.4+/-9.3 mg/100 ml) were highest when 5% sucrose was added to the ethanol solution. Moreover, the ratios between ethanol intakes and resulting BECs were approximately the same for all solutions.
These findings indicate that, under the conditions of this procedure, the BEC reached is dependent on the amount of ethanol consumed and is not influenced by the addition of sucrose to the solution.
在既不缺食也不缺水的大鼠中，向乙醇溶液中添加蔗糖会导致乙醇自我给药量大幅增加。然而，如果蔗糖改变了乙醇的吸收或代谢，导致血液乙醇浓度（BECs）与较低乙醇/水溶液摄入量所产生的浓度没有差异，那么蔗糖/乙醇混合物在增加乙醇消耗方面的效用就值得怀疑。本研究旨在确定在操作性自我给药范式中，向乙醇溶液中添加蔗糖是否会改变BECs。
在雄性Long-Evans大鼠摄入四种不同溶液（即5%蔗糖/20%乙醇、5%蔗糖/10%乙醇、2%蔗糖/10%乙醇和10%乙醇）30分钟后采集尾血。
当乙醇溶液中添加5%蔗糖时，乙醇摄入量（平均，1.57±0.21 g/kg）和BECs（平均，78.4±9.3 mg/100 ml）最高。此外，所有溶液的乙醇摄入量与所产生的BECs之间的比率大致相同。
这些发现表明，在此程序条件下，所达到的BEC取决于乙醇的消耗量，不受溶液中添加蔗糖的影响。
