Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA.
Behav Brain Res. 2011 Apr 15;218(2):346-9. doi: 10.1016/j.bbr.2010.12.017. Epub 2010 Dec 22.
Alcohol abuse in schizophrenia exceeds rates in the general population and worsens illness outcomes. Neonatal ventral hippocampal lesion (NVHL) rats model multiple schizophrenia dimensions including addiction vulnerability. This study compared NVHL vs. SHAM-controls in operant alcohol seeking and consumption. NVHLs enhanced consumption of combined ethanol/sucrose solution but neither ethanol or sucrose only solutions, consistent with increased vulnerability specific to carbohydrate-laden alcohol beverages typically consumed in early stages of human alcoholism.
精神分裂症患者的酗酒问题比普通人群更为严重，且会使病情恶化。新生大鼠海马腹侧损伤（NVHL）模型可模拟多种精神分裂症维度，包括成瘾易感性。本研究比较了 NVHL 与 SHAM 对照大鼠在操作性酒精觅药和摄取方面的表现。NVHL 大鼠增强了对混合乙醇/蔗糖溶液的摄取，但对仅含乙醇或蔗糖的溶液无此效应，这与人类酒精成瘾早期阶段通常摄入的富含碳水化合物的酒精饮料的特定易感性增加一致。
