血管活性外用剂对大鼠背部皮瓣存活的影响。
Effects of vasoactive topical agents on the survival of dorsal skin flaps in rats.
作者信息
Smith D K, Dolan R W
机构信息
Department of Otolaryngology-Head and Neck Surgery, Boston University and Medical Center, MA 02118, USA.
出版信息
Otolaryngol Head Neck Surg. 1999 Sep;121(3):220-3. doi: 10.1016/S0194-5998(99)70175-0.
OBJECTIVE
To evaluate 3 vasoactive topical agents regarding their ability to improve the survival of random skin flaps in rats.
METHOD
Thirty-five adult Sprague-Dawley rats had a single 9 x 2 cm random skin flap raised with topical application of a white petroleum ointment (control group), prostaglandin E2, minoxidil, or nitroglycerin to the flap. The effect of the agents on the viability of the flaps was evaluated.
RESULTS
The control group had an average survival area of 60.8% +/- 7.9%. The nitroglycerin and minoxidil groups were not significantly different, with an average area of survival of 60.1% +/- 8.1% and 63.3% +/- 4.7%, respectively. The prostaglandin E2 group had average area of survival of 74.2% +/- 10.5% (P = 0.002).
CONCLUSION
Prostaglandin E2 demonstrated a significant increase in flap survival. Nitroglycerin ointment and minoxidil had no beneficial effects when compared with control.
目的
评估三种血管活性外用药物改善大鼠随意皮瓣存活的能力。
方法
35只成年Sprague-Dawley大鼠制作一块9×2 cm的随意皮瓣，皮瓣局部分别涂抹白凡士林软膏（对照组）、前列腺素E2、米诺地尔或硝酸甘油。评估这些药物对皮瓣存活能力的影响。
结果
对照组皮瓣平均存活面积为60.8%±7.9%。硝酸甘油组和米诺地尔组无显著差异，平均存活面积分别为60.1%±8.1%和63.3%±4.7%。前列腺素E2组平均存活面积为74.2%±10.5%（P = 0.002）。
结论
前列腺素E2显著提高了皮瓣存活率。与对照组相比，硝酸甘油软膏和米诺地尔无有益作用。
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