外用维生素A和维生素E对缺血性随意皮瓣存活的影响。
The Effect of Topical Vitamin A and E on Ischemic Random Skin Flap Survival.
作者信息
Hassanpour Seyed Esmail, Rostami Khalil, Azargashb Eznollah, Saberi Kourosh, Hamraz Seyyed Hosein, Farajzadeh Vajari Fatemeh, Molaei Hojjat
机构信息
Department of Plastic and Reconstructive Surgery, Medicine School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Plastic and Reconstructive Surgery, Medicine School, Semnan University of Medical Sciences, Semnan, Iran.
出版信息
World J Plast Surg. 2019 Jan;8(1):58-61. doi: 10.29252/wjps.8.1.58.
BACKGROUND
Ischemia of skin flaps is an important complication in reconstructive surgery. This study evaluated the efficacy of topical vitamins A and E on improving flap survival.
METHODS
Twenty-four white-albino male rats were randomly divided into two groups of treatment and control. Standard rectangular, distally based dorsal random pattern skin flap was elevated. Intra-peritoneal cephazoline was administered to prevent any unexpected infection. No pharmaceutical agent was administered for the control group, but pure vaseline ointment. In treatment group, vaseline plus vitamins A and E were administrated daily after surgery for 10 days. The rats were evaluated on the 10 day after surgery for viable and necrotic portions of the flaps.
RESULTS
The mean values of necrosis in the flaps were 625±189.56 and 920.00±247.31 in the treatment and control groups, respectively. Vaseline plus vitamins increased flap survival significantly.
CONCLUSION
Topical vitamins A and E may be effective pharmaceutical agents to increase viability of random skin flaps in rats. They can be added to vasoactive topical agents to reach better results.
背景
皮瓣缺血是整形手术中的一种重要并发症。本研究评估了局部应用维生素A和E对提高皮瓣存活率的疗效。
方法
将24只白色白化雄性大鼠随机分为治疗组和对照组。掀起标准的远端蒂背部矩形随意型皮瓣。腹腔注射头孢唑林以预防任何意外感染。对照组不使用任何药剂，仅使用纯凡士林软膏。治疗组在术后每天给予凡士林加维生素A和E，持续10天。术后第10天对大鼠皮瓣的存活和坏死部分进行评估。
结果
治疗组和对照组皮瓣坏死的平均值分别为625±189.56和920.00±247.31。凡士林加维生素显著提高了皮瓣存活率。
结论
局部应用维生素A和E可能是提高大鼠随意型皮瓣存活率的有效药剂。它们可添加到血管活性局部用药中以获得更好的效果。
Zotero 插件