Rivas D A, Chancellor M B, Huang B, Salzman S K
Department of Urology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA.
J Spinal Cord Med. 1995 Oct;18(4):245-50. doi: 10.1080/10790268.1995.11719404.
In order to compare the erectile response to topical, intraurethral and intracorporal administration of vasoactive substances in neurologically intact and spinal cord injured (SCI) rats, a standard rat model of SCI using impact trauma at the level of T10 was employed, comparing the tumescence of 24 SCI and 25 control rats. Four weeks after SCI, the effect of vasoactive substances on erectile function was evaluated. Under ketamine anesthesia, the penis was exposed and intracorporal pressure (ICP) was monitored using saline infusion cavernosometry through a 24-gauge catheter inserted into one corpus cavernosum. Changes in ICP were recorded in response to the topical and intraurethral (IU) application of minoxidil (0.1 ml, 2% solution) and 2% nitroglycerin (NTG) ointment (0.1 gm), as well as the intracorporal (IC) administration of papaverine (0.0001-0.10 mg/kg). Results indicated that the mean baseline ICP was 8 +/- 5 mmHg for SCI and 9 +/- 4 mmHg for control rats. No response to topical therapy onto the undegloved penis was noted in either SCI or control rats. IU application of minoxidil to the degloved phallus developed ICP greater than that achieved with topical minoxidil; the topical application of NTG was less effective. In SCI rats, IC papaverine injection achieved an ICP of 56.9 +/- 24.3 mmHg, whereas papaverine in control rats generated an ICP of 43.5 +/- 38.8 mmHg. A greater increase in ICP at lower doses of each agent occurred in SCI than in control rats. We conclude that only the degloved phallus responded to topical vasoactive pharmacotherapy. Although both topical and IU applications of NTG and minoxidil increase ICP, tumescence was significantly less than that achieved with IC injection of papaverine. The IU application of minoxidil demonstrated significantly greater activity than other topical therapies. SCI rats displayed a supersensitive response to all modes of pharmacologic erectile therapy.
为了比较在神经功能正常和脊髓损伤（SCI）大鼠中，血管活性物质经局部、尿道内和海绵体内给药后的勃起反应，采用了一种在T10水平进行撞击创伤的标准SCI大鼠模型，比较24只SCI大鼠和25只对照大鼠的阴茎肿胀情况。SCI后四周，评估血管活性物质对勃起功能的影响。在氯胺酮麻醉下，暴露阴茎，并通过插入一侧海绵体的24号导管，使用盐水灌注海绵体测压法监测海绵体内压（ICP）。记录在局部和尿道内（IU）应用米诺地尔（0.1 ml，2%溶液）和2%硝酸甘油（NTG）软膏（0.1 gm）以及海绵体内（IC）注射罂粟碱（0.0001 - 0.10 mg/kg）后ICP的变化。结果表明，SCI大鼠的平均基线ICP为8±5 mmHg，对照大鼠为9±4 mmHg。在SCI大鼠和对照大鼠中，对未脱套阴茎进行局部治疗均未观察到反应。对脱套阴茎IU应用米诺地尔产生的ICP高于局部应用米诺地尔；局部应用NTG效果较差。在SCI大鼠中，IC注射罂粟碱使ICP达到56.9±24.3 mmHg，而对照大鼠中罂粟碱使ICP达到43.5±38.8 mmHg。与对照大鼠相比，SCI大鼠在每种药物较低剂量时ICP的升高幅度更大。我们得出结论，只有脱套阴茎对局部血管活性药物治疗有反应。虽然局部和IU应用NTG和米诺地尔均可增加ICP，但肿胀明显小于IC注射罂粟碱所达到的程度。IU应用米诺地尔显示出比其他局部治疗显著更强的活性。SCI大鼠对所有药物性勃起治疗模式均表现出超敏反应。
