Zalewska-Szewczyk B, Lipiec J, Bodalski J
II Clinic of Children's Diseases, Institute of Pediatrics, Medical University of Lódz.
Klin Padiatr. 1999 Jul-Aug;211(4):356-9. doi: 10.1055/s-2008-1043814.
Congestive heart failure is one the most severe late complications of cancer therapy with anthracyclines. The function of the heart muscle was evaluated in 50 children (30 boys and 20 girls), aged from 5 years 6 months to 20 years 7 months, treated in the past for lymphoblastic or nonlymphoblastic acute leukemia. The total dose of the administrated anthracyclines was 120-550 mg/m2. The circulatory system was evaluated on the basis of history, physical examination, ECG, exercise test and echocardiography. Impaired contractility of the heart muscle was found in 32% of cases. The degree of impairment was related to the total dose of anthracyclines and to the period from discontinuation of therapy. Heart muscle function disorders were present also in children, in whom the cumulative dose of anthracycline antibiotics did not exceed 400 mg/m2. In the majority of patients the evidence of heart damage was subclinical.
充血性心力衰竭是蒽环类药物癌症治疗最严重的晚期并发症之一。对50名曾接受淋巴细胞性或非淋巴细胞性急性白血病治疗的儿童（30名男孩和20名女孩，年龄从5岁6个月至20岁7个月）的心肌功能进行了评估。蒽环类药物的总给药剂量为120 - 550 mg/m²。基于病史、体格检查、心电图、运动试验和超声心动图对循环系统进行了评估。在32%的病例中发现心肌收缩力受损。受损程度与蒽环类药物的总剂量以及停药后的时间有关。蒽环类抗生素累积剂量未超过400 mg/m²的儿童也存在心肌功能障碍。在大多数患者中，心脏损伤的证据是亚临床的。
