Nilsson F M, Kessing L V, Sørensen T M, Andersen P K, Bolwig T G
Department of Psychiatry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
J Neurol Neurosurg Psychiatry. 2002 Jul;73(1):40-4. doi: 10.1136/jnnp.73.1.40.
To investigate the time relation between dementia and major affective disorders (major depression and mania).
Register linkage study of the Danish Hospital Register and the Danish Psychiatric Central Research Register, to establish study cohorts of patients with dementia and control groups (osteoarthritis or diabetes) on first discharge from hospital. Follow up of cohorts was for up to 21 years. Hazard of death was allowed for by the use of competing risks models.
Patients with dementia had an increased risk of being admitted to hospital for major depression or mania during the course of the illness. The incidence remained elevated throughout the rest of the patient's life.
Patients with dementia have an increased risk of developing depression or mania. Proper treatment of affective disorders in patients with dementia is important in reducing suffering and costs.
研究痴呆与主要情感障碍(重度抑郁和躁狂)之间的时间关系。
对丹麦医院登记册和丹麦精神病学中央研究登记册进行登记联动研究,以确定痴呆患者的研究队列以及首次出院时的对照组(骨关节炎或糖尿病患者)。对队列进行长达21年的随访。使用竞争风险模型考虑死亡风险。
痴呆患者在疾病过程中因重度抑郁或躁狂入院的风险增加。在患者的余生中,发病率一直居高不下。
痴呆患者患抑郁症或躁狂症的风险增加。对痴呆患者的情感障碍进行适当治疗对于减轻痛苦和降低成本很重要。