核苷修饰影响tRNA（Lys,3）反密码子的结构和稳定性。
Nucleoside modifications affect the structure and stability of the anticodon of tRNA(Lys,3).
作者信息
Davis D R, Durant P C
机构信息
Department of Medicinal Chemistry, University of Utah, Salt Lake City 84112, USA.
出版信息
Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1579-81. doi: 10.1080/07328319908044790.
PMID:10474235
Abstract
NMR spectroscopy was used to determine the solution structures of RNA oligonucleotides comprising the anticodon domain of tRNA(Lys,3). The structural effects of the pseudouridine modification at position 39 were investigated and are well correlated with changes in thermodynamic parameters. The loop conformation differs from that seen in tRNA(Phe) and provides an explanation of the critical role of modification in this tRNA.
摘要
核磁共振光谱法被用于确定包含tRNA（Lys，3）反密码子结构域的RNA寡核苷酸的溶液结构。研究了39位假尿苷修饰的结构效应，并且这些效应与热力学参数的变化密切相关。该环的构象不同于tRNA（Phe）中的构象，并为该tRNA中修饰的关键作用提供了解释。
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