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细胞的生物电流变学模型。8. 长时间反复剪切应力下的细胞变形。

Bioelectrorheological model of the cell. 8. Cellular deformation under prolonged and recurrent shear stress.

作者信息

Pawłowski P, Fikus M

机构信息

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego, Warsaw, Poland.

出版信息

Biorheology. 1998 Jul-Oct;35(4-5):311-24. doi: 10.1016/S0006-355X(99)80013-4.

DOI:10.1016/S0006-355X(99)80013-4
PMID:10474657
Abstract

The influence of a prolonged and recurrent shear stress created by a periodic electric field on the mechanical properties of Neurospora crassa cells was investigated. Conditions were found under which modifications of cellular structures responding to stress become irreversible, and plastic flow of the viscoelastic structural elements is observed. The symmetry of the response of the cell under stress application and relaxation was lost, when compared to the reference conditions. To interpret the results a general rheological model was proposed. As previously described (Pawłowski et al., 1997), the existence of the three hypothetical supramolecular regions of the membrane (F, S and O) was suggested. Rheological parameters for the above regions were calculated. Theoretical functions were satisfactorily fitted to the experimental results.

摘要

研究了周期性电场产生的长时间反复剪切应力对粗糙脉孢菌细胞力学性能的影响。发现了一些条件,在这些条件下,对应力作出反应的细胞结构改变变得不可逆,并且观察到粘弹性结构元件的塑性流动。与参考条件相比,在施加应力和松弛时细胞反应的对称性丧失。为了解释结果,提出了一个通用的流变模型。如先前所述(Pawłowski等人,1997年),有人提出膜存在三个假设的超分子区域(F、S和O)。计算了上述区域的流变参数。理论函数与实验结果拟合良好。

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