小鼠尿液中α1-微球蛋白和乌司他丁含量的性别和年龄相关变化。

Sex- and age-related changes in urinary contents of alpha 1-microglobulin and ulinastatin in mice.

Shikimi T, Suzuki S, Kaku K, Ishino H, Okunishi H, Takaori S

Department of Pharmacology, Shimane Medical University, Japan.

Clin Exp Pharmacol Physiol. 1999 Aug;26(8):614-7. doi: 10.1046/j.1440-1681.1999.03093.x.

Abstract

Using two murine strains, ICR/Jcl and senescence-accelerated-prone inbred mouse 1 (SAMP1), age-associated changes in urine indices (e.g. urine volume, creatinine contents, contents of alpha 1-microglobulin (alpha 1M) and ulinastatin (UT) and the relation of urinary contents of alpha 1M and UT were investigated. 2. Sex-related differences in the indices were not observed in ICR nor in SAMP1 mice. 3. Urine indices per 24 h of ICR mice at 6 and 14 months of age were higher than those at 3 months of age, although indices of SAMP1 mice did not change with ageing. Urinary contents of alpha 1M and UT in ICR mice at 6 and 14 months of age were higher than those in SAMP1 mice. However, contents of alpha 1M and UT expressed as the contents per creatinine did not differ between these two strains. 4. In the relation between urinary contents of alpha 1M and UT, a positive correlation was displayed both in ICR and SAMP1 mice, and the regression slope did not significantly differ with ageing in these two strains. 5. These results suggest that ageing per se is not a factor which affects the relation of urinary contents of alpha 1M and UT.

摘要

使用两种小鼠品系，即ICR/Jcl和衰老加速易感性近交系小鼠1（SAMP1），研究了尿液指标（如尿量、肌酐含量、α1-微球蛋白（α1M）和乌司他丁（UT）含量）与年龄相关的变化以及α1M和UT尿液含量之间的关系。2. 在ICR小鼠和SAMP1小鼠中均未观察到这些指标的性别差异。3. ICR小鼠6个月和14个月龄时每24小时的尿液指标高于3个月龄时，尽管SAMP1小鼠的指标不会随年龄变化。ICR小鼠6个月和14个月龄时α1M和UT的尿液含量高于SAMP1小鼠。然而，以每肌酐含量表示的α1M和UT含量在这两个品系之间没有差异。4. 在α1M和UT的尿液含量关系中，ICR小鼠和SAMP1小鼠均呈现正相关，并且这两个品系中回归斜率不会随年龄显著变化。5. 这些结果表明，衰老本身并不是影响α1M和UT尿液含量关系的因素。