帕金森病患者尿中α1-微球蛋白水平与乌司他丁之间不存在正相关。

Non-existence of a positive correlation between urinary levels of alpha 1-microglobulin and ulinastatin in patients with Parkinson's disease.

作者信息

Inagaki T, Shikimi T, Matsubara K, Kobayashi S, Ishino H, Okunishi H, Takaori S

机构信息

Department of Psychiatry, Shimane Medical University, Izumo, Japan.

出版信息

Psychiatry Clin Neurosci. 1996 Aug;50(4):231-3. doi: 10.1111/j.1440-1819.1996.tb02747.x.

DOI:10.1111/j.1440-1819.1996.tb02747.x

PMID:9201781

Abstract

Urinary levels of alpha 1-microglobulin (alpha 1M) and of ulinastatin (UT) and the alpha 1M/UT ratio did not differ significantly between age-matched controls and patients with Parkinson's disease, and among subdivided groups based on Yahr's stages in Parkinson's disease. Furthermore, these indexes did not correlate with Yahr's stages. Although alpha 1M and UT levels did not correlate in patients with Parkinson's disease, a positive correlation was observed in the control group. The non-existence of a positive correlation between alpha 1M and UT levels distinguishes Parkinson's disease from other neuropsychiatric diseases such as dementia (Alzheimer-type and vascular dementia), schizophrenia and mood disorder.

摘要

在年龄匹配的对照组与帕金森病患者之间，以及基于帕金森病耶尔分期细分的各组之间，尿中α1-微球蛋白（α1M）、乌司他丁（UT）水平及α1M/UT比值并无显著差异。此外，这些指标与耶尔分期无关。虽然帕金森病患者中α1M与UT水平不相关，但在对照组中观察到正相关。α1M与UT水平之间不存在正相关可将帕金森病与其他神经精神疾病如痴呆（阿尔茨海默型和血管性痴呆）、精神分裂症和情绪障碍区分开来。