Nasir L, Reid S W
Department of Veterinary Clinical Studies, University of Glasgow Veterinary School, UK.
Virus Res. 1999 Jun;61(2):171-5. doi: 10.1016/s0168-1702(99)00022-2.
The sarcoid is a benign locally invasive dermal fibroblastic lesion, commonly affecting horses and donkeys. The aetiology of the equine sarcoid is equivocal. Bovine papillomaviral (BPV) DNA (type 1/2) is frequently demonstrable in equine sarcoid tumour biopsies. However, the exact role of the virus in the disease process and its contribution to the phenotypic differences in sarcoids is not known. It was sought to assess the transcriptional activity of BPV-1 found in sarcoid tissues. Of 20 tumours examined, 18 were positive for E2 expression and ten positive for L1 expression. Viral oncogenes E5, E6 and E7 transcripts were detected in 16, nine and 12 tumours, respectively. This study demonstrates BPV gene expression in equine sarcoids and provide the first evidence for a direct involvement of the virus in the pathogenesis of sarcoids.
肉样瘤是一种良性的局部侵袭性皮肤成纤维细胞病变，常见于马和驴。马肉样瘤的病因尚不明确。在马肉样瘤肿瘤活检中经常能检测到牛乳头瘤病毒（BPV）DNA（1/2型）。然而，该病毒在疾病过程中的确切作用及其对肉样瘤表型差异的影响尚不清楚。本研究旨在评估在肉样瘤组织中发现的BPV-1的转录活性。在检测的20个肿瘤中，18个E2表达呈阳性，10个L1表达呈阳性。病毒癌基因E5、E6和E7转录本分别在16个、9个和12个肿瘤中被检测到。本研究证明了BPV基因在马肉样瘤中的表达，并首次为该病毒直接参与肉样瘤的发病机制提供了证据。
