Oishi M, Mochizuki Y
Department of Neurology, Nihon University Nerima Hikarigaoka Hospital, Tokyo, Japan.
J Neurol Sci. 1999 Jul 1;166(2):81-4. doi: 10.1016/s0022-510x(99)00116-1.
In order to find out the relationship between the cerebrovascular acetazolamide reactivity and platelet function in asymptomatic cerebral thrombosis, 10 cases of asymptomatic cerebral infarction and 10 age-matched control subjects were studied. The cerebrovascular acetazolamide reactivity was measured using xenon computed tomography method. As markers of platelet function, the plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2 were determined. The cerebrovascular acetazolamide reactivity was significantly lower in the asymptomatic cerebral infarction group than in the control group. The plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2 were higher in the asymptomatic cerebral infarction group than in the control group. There was a significant negative correlation between the cerebrovascular acetazolamide reactivity and the plasma concentrations of platelet factor 4, beta-thromboglobulin, thromboxane B2, and 11-dehydrothromboxane B2. The low cerebrovascular acetazolamide reactivity is considered to be related to platelet activation in asymptomatic cerebral thrombosis.
为了探究无症状性脑血栓形成中脑血管乙酰唑胺反应性与血小板功能之间的关系，对10例无症状性脑梗死患者和10例年龄匹配的对照者进行了研究。采用氙计算机断层扫描法测量脑血管乙酰唑胺反应性。作为血小板功能的标志物，测定了血浆中血小板因子4、β-血小板球蛋白、血栓素B2和11-脱氢血栓素B2的浓度。无症状性脑梗死组的脑血管乙酰唑胺反应性显著低于对照组。无症状性脑梗死组血浆中血小板因子4、β-血小板球蛋白、血栓素B2和11-脱氢血栓素B2的浓度高于对照组。脑血管乙酰唑胺反应性与血浆中血小板因子4、β-血小板球蛋白、血栓素B2和11-脱氢血栓素B2的浓度之间存在显著负相关。脑血管乙酰唑胺反应性降低被认为与无症状性脑血栓形成中的血小板活化有关。
