Besheer J, Jensen H C, Bevins R A
Department of Psychology, University of Nebraska-Lincoln 68588-0308, USA.
Behav Brain Res. 1999 Aug;103(1):35-44. doi: 10.1016/s0166-4328(99)00021-2.
Access to novel objects, similar to drugs of abuse, can enhance a place preference in rats. In the present experiments, the dopamine D1 receptor antagonist SCH-23390 blocked an increase in place preference conditioned by access to novel objects at doses that did not interfere with object interaction (0.01 and 0.03 mg/kg) or produce a place aversion in controls. However, eticlopride, a D2/D3 dopamine receptor antagonist, only blocked the conditioned increase in place preference at a dose (0.3 mg/kg) that impaired object interaction. In contrast, neither SCH-23390 nor eticlopride blocked preference for the novel object in an object recognition task at doses that did not interfere with object interaction. These experiments provide further evidence that the neural processes controlling learned associations between novel stimuli and the environment overlap with drugs of abuse.
接触新异物体，类似于滥用药物，可增强大鼠的位置偏爱。在本实验中，多巴胺D1受体拮抗剂SCH-23390在不干扰物体交互作用的剂量（0.01和0.03mg/kg）下，阻断了由接触新异物体所条件化的位置偏爱增加，且在对照组中未产生位置厌恶。然而，D2/D3多巴胺受体拮抗剂依托必利仅在损害物体交互作用的剂量（0.3mg/kg）下，阻断了条件化的位置偏爱增加。相反，在不干扰物体交互作用的剂量下，SCH-23390和依托必利在物体识别任务中均未阻断对新异物体的偏爱。这些实验提供了进一步的证据，表明控制新异刺激与环境之间习得关联的神经过程与滥用药物的神经过程重叠。
