Nentwig Todd B, Myers Kevin P, Grisel Judith E
Department of Psychology, Graduate Program at Bucknell University, One Dent Drive, Lewisburg, PA 17837, USA.
Department of Psychology, Neuroscience Program at Bucknell University, One Dent Drive, Lewisburg, PA 17837, USA.
Alcohol. 2017 Feb;58:19-22. doi: 10.1016/j.alcohol.2016.11.005. Epub 2016 Nov 23.
Initial subjective response to the rewarding properties of alcohol predicts voluntary consumption and the risk for alcohol use disorders. We assessed the initial subjective reward to alcohol in rats using a single exposure conditioned place preference (SE-CPP) paradigm. Sprague-Dawley rats demonstrate preference for a context paired with a single systemic injection of ethanol (1.0 g/kg, delivered intraperitoneally). However, expression of SE-CPP in males depended on pairing ethanol with the first exposure of two (ethanol; saline) to the conditioning apparatus and procedures, while conditioning day did not appreciably affect SE-CPP in females, consistent with the view that females experience heightened addiction vulnerability. This model offers researchers a high throughput assay for investigating factors that influence alcohol reward and may point the way toward more effective prevention and treatment efforts.
对酒精奖赏特性的初始主观反应可预测自愿饮酒行为及酒精使用障碍的风险。我们使用单次暴露条件性位置偏爱（SE-CPP）范式评估了大鼠对酒精的初始主观奖赏。斯普拉格-道利大鼠表现出对与单次腹腔注射乙醇（1.0 g/kg）配对的环境的偏爱。然而，雄性大鼠中SE-CPP的表现取决于将乙醇与对条件化装置和程序的两次暴露中的第一次（乙醇；生理盐水）配对，而条件化日对雌性大鼠的SE-CPP没有明显影响，这与雌性成瘾易感性更高的观点一致。该模型为研究人员提供了一种高通量检测方法，用于研究影响酒精奖赏的因素，并可能为更有效的预防和治疗措施指明方向。
