Gurevitch J, Paz Y, Shapira I, Matsa M, Kramer A, Pevni D, Lev-Ran O, Moshkovitz Y, Mohr R
Department of Thoracic and Cardiovascular Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
Ann Thorac Surg. 1999 Aug;68(2):406-11; discussion 412. doi: 10.1016/s0003-4975(99)00460-9.
Complete arterial myocardial revascularization without the use of saphenous veins grafts was primarily performed on selected patient populations such as the young and nondiabetic. In a recently developed surgical technique, the internal mammary artery is dissected gently as a longer skeletonized artery, providing greater versatility for complete arterial revascularization, without saphenous veins grafts.
We prospectively evaluated the impact of the routine use of double skeletonized internal mammary artery in 472 patients who underwent coronary artery bypass grafting between April 1996 and June 1997. Their average age was 65 years (30 to 87 years), 383 (83%) were men, and 89 (17%) women. One hundred sixty-nine (36%) of the patients were older than 70 years, and 145 (31%) were diabetic. The average number of grafts was 3.2 per patient (two to six grafts).
Operative mortality was 1.7% (n = 8). The mortality of urgent and elective patients was 0.7% (3 of 410 patients), and that of emergency operations was 8.1% (5 of 62 patients; p < 0.01). There were three (0.6%) perioperative infarcts, and 6 patients (1.3%) sustained strokes. Sternal wound infection occurred in 8 patients (1.7%). Postoperative follow-up (1 to 25 months) was available in 462 patients (99%). Two-year actuarial survival was 96.8%, and 92% of the surviving patients are well and free of angina. Neither diabetes mellitus nor old age (>70 years) were significant independent predictors of any early or late untoward events. None of the 70 diabetic patients more than 65 years of age developed sternal wound infection. Chronic lung disease was found to be the only independent predictor for sternal infections.
Routine use of bilateral skeletonized internal mammary artery is a safe replacement for the current myocardial revascularization technique even in the old and diabetic patients.
不使用大隐静脉移植进行完全动脉化心肌血运重建主要应用于特定患者群体,如年轻人和非糖尿病患者。在一项最近开发的手术技术中,将胸廓内动脉轻柔地游离成更长的骨骼化动脉,为不使用大隐静脉移植的完全动脉化血运重建提供了更大的灵活性。
我们前瞻性评估了1996年4月至1997年6月间接受冠状动脉旁路移植术的472例患者常规使用双侧骨骼化胸廓内动脉的影响。他们的平均年龄为65岁(30至87岁),383例(83%)为男性,89例(17%)为女性。169例(36%)患者年龄超过70岁,145例(31%)患有糖尿病。每位患者平均移植血管数为3.2根(2至6根)。
手术死亡率为1.7%(n = 8)。急诊和择期手术患者的死亡率为0.7%(410例患者中的3例),急诊手术患者的死亡率为8.1%(62例患者中的5例;p < 0.01)。围手术期发生3例(0.6%)梗死,6例患者(1.3%)发生中风。8例患者(1.7%)发生胸骨伤口感染。462例患者(99%)获得术后随访(1至25个月)。两年精算生存率为96.8%,92%的存活患者情况良好且无心绞痛。糖尿病和高龄(>70岁)均不是任何早期或晚期不良事件的显著独立预测因素。70例65岁以上的糖尿病患者均未发生胸骨伤口感染。发现慢性肺病是胸骨感染的唯一独立预测因素。
即使对于老年和糖尿病患者,常规使用双侧骨骼化胸廓内动脉也是当前心肌血运重建技术的安全替代方法。