Gross D K, Morley P S, Hinchcliff K W, Wittum T E
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus 43210, USA.
J Am Vet Med Assoc. 1999 Sep 1;215(5):670-5.
To determine the effect of furosemide on performance of Thoroughbreds racing on dirt surfaces at tracks in the United States and Canada.
Cross-sectional study.
All Thoroughbreds (n = 22,589) that finished a race on dirt surfaces at tracks in the United States and Canada between June 28 and July 13, 1997 in jurisdictions that allowed the use of furosemide.
Race records were analyzed by use of multivariable ANOVA procedures and logistic regression analyses to determine the effect of furosemide on estimated 6-furlong race time, estimated racing speed, race earnings, and finish position. Principal component analysis was used to create orthogonal scores from multiple collinear variables for inclusion in the models.
Furosemide was administered to 16,761 (74.2%) horses. Horses that received furosemide raced faster, earned more money, and were more likely to win or finish in the top 3 positions than horses that did not. The magnitude of the effect of furosemide on estimated 6-furlong race time varied with sex, with the greatest effect in males. When comparing horses of the same sex, horses receiving furosemide had an estimated 6-furlong race time that ranged from 0.56 +/- 0.04 seconds (least-squares mean +/- SE) to 1.09 +/- 0.07 seconds less than that for horses not receiving furosemide, a difference equivalent to 3 to 5.5 lengths.
Because of the pervasive use of furosemide and its apparent association with superior performance in Thoroughbred racehorses, further consideration of the use of furosemide and investigation of its effects in horses is warranted.
确定呋塞米对在美国和加拿大赛道上进行泥地赛事的纯种马比赛表现的影响。
横断面研究。
1997年6月28日至7月13日期间,在美国和加拿大允许使用呋塞米的辖区内,在泥地赛道上完成比赛的所有纯种马(n = 22,589)。
通过多变量方差分析程序和逻辑回归分析对比赛记录进行分析,以确定呋塞米对估计的6弗隆比赛时间、估计的比赛速度、比赛奖金和完赛名次的影响。主成分分析用于从多个共线变量创建正交分数,以纳入模型。
16,761匹(74.2%)马使用了呋塞米。与未使用呋塞米的马相比,使用呋塞米的马跑得更快,赢得的奖金更多,并且更有可能获胜或获得前三名。呋塞米对估计的6弗隆比赛时间的影响程度因性别而异,对雄性马的影响最大。在比较相同性别的马时,使用呋塞米的马的估计6弗隆比赛时间比未使用呋塞米的马少0.56±0.04秒(最小二乘均值±标准误)至1.09±0.07秒,这一差异相当于3至5.5个马身长度。
由于呋塞米的广泛使用及其与纯种赛马卓越表现的明显关联,有必要进一步考虑呋塞米的使用并对其在马匹中的作用进行研究。