Günhan O, Günhan M, Berker E, Gürgan C A, Yildirim H
Department of Pathology, Gülhane Military Medical Academy, Ankara, Turkey.
J Periodontol. 1999 Aug;70(8):919-25. doi: 10.1902/jop.1999.70.8.919.
Generalized membranous gingival enlargement due to accumulation of amyloid or fibrin-like material is a rare, destructive and poorly defined disease entity. Some patients also show extraoral manifestations. The lesion is an involvement of periodontal tissues caused by the same process as ligneous conjunctivitis. In this report, 3 new cases, two of whom are siblings, are presented. Defective fibrinolysis and abnormal wound healing seem to be the main pathogenetic mechanism of this unusual disease, which should be evaluated systemically considering other mucosal involvement.
由于淀粉样蛋白或纤维蛋白样物质积聚导致的广泛性膜性牙龈肿大是一种罕见、具有破坏性且定义不明确的疾病实体。一些患者还表现出口腔外表现。该病变是由与木质化结膜炎相同的过程引起的牙周组织受累。在本报告中，介绍了3例新病例，其中2例是 siblings（此处可能有误，推测为“siblings”，意为“兄弟姐妹”）。纤维蛋白溶解缺陷和异常伤口愈合似乎是这种罕见疾病的主要发病机制，应综合考虑其他黏膜受累情况进行全身评估。
