Shizgal H M
Can J Surg. 1978 Nov;21(6):483-8.
Body composition measurements were determined by a multiple isotope dilution technique to assess nutritional status of patients and to determine the efficacy of nutritional support. The body composition of 75 patients with severe malnutrition was characterized by a contracted body cell mass with a relatively expanded extracellular mass. An elective operation of moderate severity resulted in a 14% decrease in the body cell mass while the extracellular mass increased by 10%. The 4% postoperative decrease in body weight did not accurately reflect the change in the body cell mass. The efficacy of total parenteral nutrition (TPN) with lipid as the major caloric source was compared with TPN with hypertonic dextrose. With lipid a daily infusion of 44.2 Cal/kg (185 kJ/kg) was required to maintain the body cell mass while with the solution containing hypertonic dextrose 34.7 Cal/kg (155 kJ/kg) was required--a 27% difference. Total parenteral nutrition with hypertonic dextrose is therefore more efficacious than TPN with lipid as the major caloric source.
采用多种同位素稀释技术测定身体成分，以评估患者的营养状况并确定营养支持的效果。75例严重营养不良患者的身体成分特点是体细胞群缩小，细胞外质量相对增加。中度择期手术导致体细胞群减少14%，而细胞外质量增加10%。术后体重下降4%并不能准确反映体细胞群的变化。比较了以脂质作为主要热量来源的全胃肠外营养（TPN）与以高渗葡萄糖为基础的TPN的效果。使用脂质时，每日输注44.2千卡/千克（185千焦/千克）才能维持体细胞群，而使用含高渗葡萄糖的溶液时，则需要34.7千卡/千克（155千焦/千克）——相差27%。因此，以高渗葡萄糖为基础的全胃肠外营养比以脂质作为主要热量来源的TPN更有效。
