病例报告：犬的巨球蛋白血症

Mejia E B, Carman S, Lumsden J H

Can Vet J. 1979 Jan;20(1):28-33.

This report describes a case of macroglobulinemia in a six year old castrate male Collie cross dog with clinical signs of epistaxis, anemia, retinopathy and high serum viscosity. The highest total serum protein was 12 g/dl with approximately 60% monoclonal beta globulin. Proteinuria, Bence Jones protein and osteolytic lesions were not detected.Chemotherapy and partial removal of the plasma protein by withdrawal of whole blood and transfusion with packed red cells from a DEA negative donor resulted in transient clinical remission.

本报告描述了一例6岁去势杂种柯利犬患巨球蛋白血症的病例，该犬有鼻出血、贫血、视网膜病变和高血清粘度等临床症状。血清总蛋白最高为12g/dl，约60%为单克隆β球蛋白。未检测到蛋白尿、本-周蛋白和溶骨性病变。化疗以及通过抽取全血和输注来自DEA阴性供体的浓缩红细胞部分去除血浆蛋白后，临床症状出现短暂缓解。