MacEwen E G, Hurvitz A I, Hayes A
J Am Vet Med Assoc. 1977 Jun 1;170(11):1309-12.
Hyperviscosity syndrome was associated with increased plasma content of monoclonal immunoglobulin (IgA or IgM) in 3 dogs with lymphocytic leukemia. The diagnosis of lymphocytic leukemia was based on the finding of a large number of mature lymphocytes in the blood and bone marrow. The clinical signs included weakness, lethargy, depression, and coughing due to congestive heart failure. Consistent physical findings were splenomegaly, with or without peripheral lymphadenopathy, and funduscopic abnormalities. Of the 2 dogs treated successfully with chlorambucil, 1 remains in remission after withdrawal of the drug for over 1 year.
高黏滞综合征与3只患淋巴细胞白血病的犬血浆中单克隆免疫球蛋白（IgA或IgM）含量增加有关。淋巴细胞白血病的诊断基于血液和骨髓中发现大量成熟淋巴细胞。临床症状包括因充血性心力衰竭导致的虚弱、嗜睡、抑郁和咳嗽。体格检查的一致发现是脾肿大，伴有或不伴有外周淋巴结病，以及眼底异常。在2只成功接受苯丁酸氮芥治疗的犬中，1只在停药1年多后仍处于缓解期。
