饮食中牛磺酸对喂食含苯巴比妥饮食的大鼠内源性高胆固醇血症的影响。

Effect of dietary taurine on endogenous hypercholesterolemia in rats fed on phenobarbital-containing diets.

作者信息

Mochizuki H, Takido J, Yokogoshi H

机构信息

School of Food and Nutritional Sciences, University of Shizuoka, Japan.

出版信息

Biosci Biotechnol Biochem. 1999 Jul;63(7):1298-300. doi: 10.1271/bbb.63.1298.

DOI:10.1271/bbb.63.1298

PMID:10478458

Abstract

The effect of dietary taurine on endogenous hypercholesterolemia induced by a phenobarbital-containing diet was investigated. Supplemented taurine did not affect the concentrations of serum cholesterol, but further potentiated the accumulation of hepatic cholesterol in the hypercholesterolemic state induced by phenobarbital. It is suggested that taurine might amplify the hepatic cholesterogenesis in phenobarbital-induced hypercholesterolemia.

摘要

研究了膳食牛磺酸对含苯巴比妥饮食诱导的内源性高胆固醇血症的影响。补充牛磺酸不影响血清胆固醇浓度，但在苯巴比妥诱导的高胆固醇血症状态下，进一步增强了肝脏胆固醇的积累。提示牛磺酸可能会增强苯巴比妥诱导的高胆固醇血症中的肝脏胆固醇生成。