Baliou Stella, Adamaki Maria, Ioannou Petros, Pappa Aglaia, Panayiotidis Mihalis I, Christodoulou Ioannis, Spandidos Demetrios A, Kyriakopoulos Anthony M, Zoumpourlis Vassilis
Institute of Chemical Biology, National Hellenic Research Foundation, 11635 Athens, Greece.
Department of Internal Medicine and Infectious Diseases, University Hospital of Heraklion, 71110 Heraklion, Greece.
Med Int (Lond). 2021 May 31;1(2):3. doi: 10.3892/mi.2021.3. eCollection 2021 May-Jun.
To develop novel therapeutic methods for both diabetic and renal disorders, scientists had initially focused on elucidating the molecular mechanisms of taurine in established cell lines and mouse models. Although a large amount of data have been revealed, taurine has been confirmed to be the next step of novel promising therapeutic interventions against diabetic disorders. Taurine appears to ameliorate diabetes 1-related complications in various organs through its antioxidant, anti-inflammatory and anti-hormonal actions. In type 2 diabetes, taurine has been positively implicated in glucose homeostasis, exerting potent hypoglycemic, anti-obesity, hypotensive and hypolipidemic effects. Of particular interest is that taurine provides protection against renal dysfunction, including hypertension and proteinuria, specific glomerular and tubular disorders, acute and chronic renal conditions, and diabetic nephropathy. The ameliorative effects of taurine against renal disorders are based on its osmoregulatory properties, its association with signaling pathways and its association with the renin-angiotensin-aldosterone system (RAAS). Further clinical studies are required to ensure the importance of research findings.
为了开发针对糖尿病和肾脏疾病的新型治疗方法，科学家们最初专注于在已建立的细胞系和小鼠模型中阐明牛磺酸的分子机制。尽管已经揭示了大量数据，但牛磺酸已被确认为针对糖尿病疾病的新型有前景治疗干预措施的下一步。牛磺酸似乎通过其抗氧化、抗炎和抗激素作用改善与1型糖尿病相关的各种器官并发症。在2型糖尿病中，牛磺酸与葡萄糖稳态呈正相关，具有强大的降血糖、抗肥胖、降血压和降血脂作用。特别值得关注的是，牛磺酸可预防肾功能障碍，包括高血压和蛋白尿、特定的肾小球和肾小管疾病、急慢性肾脏疾病以及糖尿病肾病。牛磺酸对肾脏疾病的改善作用基于其渗透调节特性、与信号通路的关联以及与肾素-血管紧张素-醛固酮系统（RAAS）的关联。需要进一步的临床研究来确保研究结果的重要性。
